Introduction
Selank is a synthetic heptapeptide derived from the endogenous immunomodulatory peptide Tuftsin. Its sequence, Thr-Lys-Pro-Arg-Pro-Gly-Pro, was engineered for enhanced stability, resistance to enzymatic degradation, and improved neuromodulatory properties. Research explores Selank’s potential influence on neurotransmitter regulation, stress-response signaling, BDNF-associated pathways, immune–neural communication, and cognitive processing networks.
Structural Biology of Selank
Selank is structurally based on the Thr-Lys-Pro-Arg motif of Tuftsin, extended with Pro-Gly-Pro to enhance conformational stability and metabolic resistance. The additional residues increase peptide rigidity, improve receptor interactions in research models, and reduce susceptibility to peptidases.
Mechanistic Pathways in Neuromodulatory Research
Selank is studied for its influence on neurotransmitter and neuroimmune systems. Research indicates potential modulation of GABA turnover, GABA synthesis enzymes, and GABA-A receptor-associated functions. Additional findings examine Selank’s relationships with serotonergic and catecholaminergic signaling, including serotonin synthesis, dopamine turnover, and norepinephrine-related stress pathways.
BDNF-Associated Pathways
Research models show Selank may influence brain-derived neurotrophic factor (BDNF) expression and associated transcriptional networks. BDNF is involved in synaptic plasticity, neuronal survival, dendritic branching, and learning mechanisms. Selank also appears in studies exploring TrkB receptor-associated pathways that govern long-term potentiation and neural adaptation.
Neuroimmune Modulation
Due to its Tuftsin origin, Selank retains relevance in immune-related pathways. Studies evaluate its effects on cytokine expression patterns, including IL-6, TNF-α, and interferon-linked signaling. Additional models explore microglial activity, including inflammatory gene expression, neuroimmune communication, and synaptic-environment regulation.
Stress-Response and HPA-Axis Research
Selank is examined in research involving corticotropin-releasing factor (CRF), hypothalamic–pituitary–adrenal (HPA) axis signaling, and stress-peptide pathways. These models explore the compound’s potential influence on adaptive and maladaptive stress-response systems.
Synaptic Plasticity and Cognitive Pathways
Studies on hippocampal gene expression suggest Selank’s involvement in regulating synaptic proteins, kinase pathways, neurotransmitter receptor expression, and immediate-early genes such as c-Fos and Arc. Research also explores Selank’s potential effects on neural oscillations, theta–gamma coupling, and excitatory–inhibitory balance.
Metabolic and Monoamine Regulation
Research involving Selank includes examination of monoamine oxidase (MAO) activity, COMT metabolic pathways, glutamate/GABA homeostasis, and tryptophan–kynurenine balance. These pathways highlight the compound’s broad neurometabolic relevance.
Summary
Selank is a Tuftsin-derived heptapeptide studied for its neuromodulatory and neuroimmune regulatory properties. Research highlights its involvement in neurotransmitter systems, BDNF-associated pathways, stress-response regulation, microglial activity, synaptic plasticity, and monoamine metabolism. Its structural stability and dual neuroimmune positioning make Selank a valuable tool in advanced neurobiological research.
Educational & Research Disclaimer
This article is for educational and scientific research purposes only. No therapeutic claims or usage recommendations are provided. Compounds referenced are not approved for human use and are intended solely for controlled laboratory experimentation.
Selank is a synthetic heptapeptide derived from the endogenous immunomodulatory peptide tuftsin. It has been studied in experimental models for its role in neuromodulatory signaling and immune–neural communication.
In the scientific literature, Selank is classified as a neuromodulatory peptide and is primarily investigated in preclinical and mechanistic research models rather than clinical therapeutic contexts.
Research involving Selank has examined pathways related to neurotransmitter regulation, stress-response signaling, immune–neural interactions, and BDNF-associated neuromodulatory networks.
No. Selank is supplied strictly for laboratory and research use. It is not approved for human consumption, medical treatment, or clinical application.
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Selank 10mg is a research compound explored for its role in neuropeptide signaling, stress-response regulation, neurotransmitter modulation, and cognitive pathway research in controlled laboratory models.
