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Description

Disclaimer:

For research use only. Not for human consumption. Intended for laboratory-based studies by qualified professionals. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.

 

Overview:
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide (MDP) studied for its role in cellular metabolism, stress resistance, and energy regulation. It is naturally encoded within mitochondrial DNA and has been shown to influence metabolic homeostasis, insulin sensitivity, and adaptive cellular responses to stress—making it a key target in metabolic and longevity research.

Mechanism of Action:
MOTS-c enhances AMP-activated protein kinase (AMPK) signaling, a central regulator of cellular energy balance. By activating AMPK and downstream metabolic pathways, it promotes glucose uptake, fatty-acid oxidation, and mitochondrial biogenesis. In preclinical studies, MOTS-c has also been shown to translocate to the nucleus under metabolic stress, where it regulates genes involved in oxidative metabolism and cellular protection.

Research Highlights:

  • Demonstrated improved glucose tolerance and insulin sensitivity in preclinical metabolic models.
  • Shown to increase exercise capacity and mitochondrial efficiency.
  • Studied for potential applications in aging, obesity, and type 2 diabetes research.
  • Regulates cellular resilience to oxidative and metabolic stress through AMPK activation and gene expression modulation.

Specifications:
Form: Lyophilized powder (research-grade)
Purity: ≥98% (HPLC-tested)
Storage: Store refrigerated (2–8 °C), protected from light and moisture.

FAQ
What is MOTS-c 10mg studied for in research models?
MOTS-c is studied for its involvement in mitochondrial-derived signaling, metabolic regulation, AMPK-associated pathways, and cellular stress adaptation in laboratory models.

Is this product intended for human use?
No. This product is for laboratory research use only and is not intended for human consumption.

What does the 10mg designation indicate?
The 10mg label refers to the quantity of the research compound provided for controlled laboratory research applications.

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