IGF-1 DES 2mg
<h2IGF1 DES 2mg</h2 <pIGF1 DES (Des(13) IGF1) is a naturally occurring truncated analogue of InsulinLike Growth Factor1 (IGF1), lacking the first three Nterminal amino acids. This structural modification significantly reduces binding affinity to IGFbinding proteins (IGFBPs), resulting in markedly enhanced bioavailability and potency compared to fulllength IGF1. Supplied as a lyophilized powder in a sterile 2mg vial, verified at ≥99% purity by HPLC.</p <h3Molecular Profile</h3 <ul <li<strongFull Name:</strong Des(13) InsulinLike Growth Factor1</li <li<strongMolecular Formula:</strong C₃₃₁H₅₁₂N₉₂O₁₀₁S₇</li <li<strongMolecular Weight:</strong 7370.5 Da</li <li<strongCAS Number:</strong 112603357</li <li<strongAmino Acids:</strong 67 (truncated from fulllength 70 aa IGF1)</li <li<strongReceptor:</strong IGF1R (insulinlike growth factor 1 receptor)</li </ul <h3Preclinical & In Vitro Data</h3 <ul <liDemonstrates 10fold greater potency than fulllength IGF1 in cell proliferation assays due to reduced IGFBP binding</li <liActivates IGF1R → PI3K/Akt and MAPK/ERK signaling cascades in muscle cell and fibroblast cultures</li <liStudied in satellite cell activation models for skeletal muscle hypertrophy and repair</li <liNeuroprotective effects documented in neuronal cell lines — promotes survival and differentiation</li <liInvestigated in cartilage and connective tissue repair models via chondrocyte proliferation studies</li <liFaster receptor dissociation kinetics compared to IGF1 LR3 — useful for shortwindow stimulation protocols in vitro</li </ul <h3Specifications</h3 <ul <liForm: Lyophilized powder</li <liAmount: 2mg per vial</li <liPurity: ≥99% (HPLCverified)</li <liStorage: 20°C (lyophilized); reconstituted solutions stable at 4°C for up to 7 days</li <liSolubility: Soluble in sterile water or 0.1% acetic acid at ≥1mg/mL</li </ul <p<strongFor Research Use Only. Not for Human Consumption.</strong</p Purity specification: ≥99% Purity HPLC. CAS number: 946870-92-4. Category: Growth Factors.
For research use only. Not for human consumption.