Overview
TB-500 is a synthetic peptide fragment derived from thymosin beta-4 (Tβ4), a naturally occurring 43-amino-acid protein found in most tissues and cell types. This peptide fragment was developed to study the regenerative and tissue-healing properties attributed to the parent protein. Research surrounding TB-500 has primarily focused on wound repair, angiogenesis, inflammation modulation, and cellular migration.
Mechanism of Action (Research Context)
Research suggests that TB-500 exerts its biological activity through the regulation of actin polymerization—a critical process in cell motility and tissue remodeling. It enhances keratinocyte and endothelial cell migration, promotes angiogenesis, and aids in cytoskeletal reorganization. Studies have demonstrated its role in upregulating vascular endothelial growth factor (VEGF) expression and modulating inflammation through cytokine pathways.
Potential Research Benefits
• Accelerated wound healing and tissue regeneration in pre-clinical studies• Enhanced angiogenesis and blood vessel formation• Reduced inflammatory response and fibrosis• Improved recovery outcomes in muscle, tendon, and ligament injury models• Investigated for potential cardiac repair properties following ischemic damage
Chemical / Physical Information
• Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Lys-Leu-Lys-Glu-Val-Thr-Asp• Molecular Weight: Approximately 4964 Da• Solubility: Soluble in sterile water or aqueous buffers• Storage: Lyophilized powder should be stored at -20°C; reconstituted solutions should be aliquoted and frozen to avoid repeated freeze-thaw cycles
Regulatory & Compliance Notes
TB-500 is not approved for therapeutic or medical use by any major regulatory authority. It is intended for research and laboratory investigation only. Procurement, handling, and storage should comply with institutional and legal requirements governing research chemicals.
References
1. Huff T. et al., J Biol Chem. (2001). The role of thymosin beta-4 in actin binding and cell motility.2. Malinda K.M. et al., J Invest Dermatol. (1999). Thymosin beta-4 accelerates wound healing.3. Sosne G. et al., Exp Eye Res. (2002). Anti-inflammatory properties of thymosin beta-4.4. Philp D. et al., Ann N Y Acad Sci. (2012). Angiogenesis and cardiac repair mechanisms of thymosin beta-4.
Disclaimer
This content is intended for research and educational purposes only. TB-500 is not approved for human or veterinary use. All studies and experimental work involving TB-500 should be conducted in compliance with applicable regulations, ethical standards, and laboratory safety protocols.
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Selected References
PMID: 18583549 — Thymosin β4–mediated tissue repair and regeneration
PMID: 19189304 — Actin-sequestering peptides in wound healing
PMID: 21440617 — Thymosin β4 pathways in angiogenesis and cellular migration
PMID: 24513106 — Peptide-driven repair mechanisms in musculoskeletal injury
Frontiers in Pharmacology — Regenerative peptides and cytoskeletal modulation
Journal of Peptide Science — Thymosin-derived peptides in tissue recovery
TB-500 is a synthetic version of a portion of thymosin beta-4 (Tβ4), studied for its potential roles in cellular migration, tissue repair, and actin regulation in research environments.
Research suggests TB-500 interacts with actin-binding pathways, influencing cell movement, angiogenesis, and regeneration markers in experimental models.
No. TB-500 discussed here is a research-only compound and is not approved for therapeutic or consumer use.
Studies explore TB-500 in contexts such as soft tissue repair, inflammation balance, angiogenesis, and cellular migration dynamics.
TB-500 is a shorter synthetic fragment containing the active region associated with actin modulation, while Tβ4 is a naturally occurring, full-length 43–amino acid peptide.
TB-500 is assessed through in vitro assays and animal studies monitoring tissue regeneration, actin expression patterns, and inflammatory markers.
Published preclinical data show generally favorable tolerability, but long-term safety profiles are not established.
Related Research Compounds
Bronchogen: Short Peptide Bioregulator for Bronchial and Pulmonary Tissue Research
TB-500 10mg is a research compound explored for its role in cytoskeletal regulation, cellular migration signaling, angiogenic pathway modulation, and regenerative mechanism research in controlled laboratory models.
